读医学网

More than 25% of the U.S. population aged 65 years has diabetes mellitus (hereafter referred to as diabetes),1 and the aging of the overall population is a significant driver of the diabetes epidemic. Although the burden of diabetes is often described in terms of its impact on working-age adults, diabetes in older adults is linked to higher mortality, reduced functional status, and increased risk of institutionalization.2 Older adults with diabetes are at substantial risk for both acute and chronic microvascular and cardiovascular complications of the disease.

Despite having the highest prevalence of diabetes of any age-group, older persons and/or those with multiple comorbidities have often been excluded from randomized controlled trials of treatments—and treatment targets for diabetes and its associated conditions. Heterogeneity of health status of older adults (even within an age range) and the dearth of evidence from clinical trials present challenges to determining standard intervention strategies that fit all older adults. To address these issues, the American Diabetes Association (ADA) convened a Consensus Development Conference on Diabetes and Older Adults (defined as those aged 65 years) in February 2012. Following a series of scientific presentations by experts in the field, the writing group independently developed this consensus report to address the following questions:

1 What is the epidemiology and pathogenesis of diabetes in older adults?

2 What is the evidence for preventing and treating diabetes and its common comorbidities in older adults?

3 What current guidelines exist for treating diabetes in older adults?

4 What issues need to be considered in individualizing treatment recommendations for older adults?

5 What are consensus recommendations for treating older adults with or at risk for diabetes?

6 How can gaps in the evidence best be filled?