发布时间:2014-07-16 18:20 类别:医学前沿资讯 标签:疗效 肿瘤 患者 治疗 结直肠癌 FIRE-3试验 性别 原发肿瘤的位置 来源:医脉通
FIRE-3试验旨在比较一线使用FOLFIRI方案联合西妥昔单抗或贝伐单抗治疗592 KRAS基因外显子2野生型转移性结直肠癌患者的疗效。我们在RAS野生型人群(n = 342)中分析性别和原发肿瘤的位置与疗效的关系。
研究方法
原发肿瘤的位置被定义如下:右侧CRC(RCRC):盲囊至结肠右曲;左侧CRC(LCRC):脾曲到直肠。横结肠肿瘤(9例)被排除在外。应用两侧的Fisher检验和对数秩检验分别计算两个治疗组中治疗反应(ORR)和生存期(PFS / OS)的差异。
研究结果
与RCRC相比,LCRC表现出更好的疗效(ORR,PFS和OS),特别是在西妥昔单抗治疗组(表)。与男性患者相比,女性患者有更低的肿瘤反应率,较短的PFS和OS的趋势。
结论
mCRC是一种异质性疾病。治疗的效果取决于原发肿瘤的位置和患者的性别。接受FOLFIRI+西妥昔单抗治疗的男性、左侧CRC患者,疗效更突出。
医脉通整理报道,转载请注明出处。
会议专题》》》2014年ASCO年会专题报道
阅读原文摘要
Gender and tumor location as predictors for efficacy: Influence on endpoints in first-line treatment with FOLFIRI in combination with cetuximab or bevacizumab in the AIO KRK 0306 (FIRE3) trial.(Abstract Number:3600)
Authors: Volker Heinemann, Dominik Paul Modest, Ludwig Fischer von Weikersthal,et al.
Session Type: General Poster Session
Background: FIRE-3 compared first-line therapy with FOLFIRI plus either cetuximab or bevacizumab in 592 KRAS exon 2 wild-type mCRC patients. We analyzed the efficacy dependent on gender and primary tumor location within the RAS wild-type population (n=342).
Methods: Primary tumor location was defined as follows: right sided CRC (RCRC): coecum to hepatic flexure; left sided CRC (LCRC): splenic flexure to rectum. Colon transversum tumors (n=9) were excluded. Differences in response (ORR) and survival (PFS/OS) within both treatment arms were calculated using two-sided Fisher′s exact and logrank test, respectively.
Results: In location wise comparison LCRC shows better efficacy results (ORR, PFS and OS) when compared with RCRC especially in the cetuximab arm (Table). Female gender has a trend towards lower tumor response rates, shorter PFS and OS when compared to male patients.
Conclusions: MCRC is a heterogeneous disease. Treatment efficacy depends on primary tumor location and patients’ gender. Effects were more prominent in patients receiving FOLFIRI plus cetuximab where male patients with LCRC tumors are favored.
读医学网 www.duyixue.com 本站转载文章版权归原作者所有,如侵犯了您的权益,请发邮件至kanyixue@yi20.com.cn,我们将会及时删除内容